Effect of ibogaine on naloxone-precipitated withdrawal syndrome in chronic morphine-dependent rats.
نویسندگان
چکیده
Ibogaine, an indole alkaloid, administered intracerebroventricularly 4-16 micrograms, attenuated a naloxone-precipitated withdrawal syndrome in chronic morphine-dependent rats. It appears that ibogaine has a more consistent effect on certain selective withdrawal signs related to the locomotion. This might explain an attenuating effect of ibogaine on some withdrawal signs. However, due to complex interaction of ibogaine with serotonin and other neurotransmitter systems, the mechanism of ibogaine antiwithdrawal effect remains unknown and requires further elucidation.
منابع مشابه
The inhibitory effect of norharman on morphine withdrawal syndrome in rats: comparison with ibogaine.
Norharman (20 mg/kg, i.p.) and ibogaine (40 mg/kg, i.p.) significantly attenuated naloxone (4 mg/kg, i.p.)-precipitated withdrawal syndrome in morphine-dependent rats. Several withdrawal signs, such as teeth-chattering, chewing, penile licking and diarrhoea, were decreased by both norharman and ibogaine. In addition, norharman reduced also the withdrawal grooming and rearing. It is concluded th...
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ورودعنوان ژورنال:
- Archives internationales de pharmacodynamie et de therapie
دوره 294 شماره
صفحات -
تاریخ انتشار 1988